Maricopa Community Colleges  NMT202   19906-20032 
Official Course Description: MCCCD Approval: 04/22/03
NMT202 19906-20032 LEC 1 Credit(s) 1 Period(s)
Radiation Biology
Qualitative and quantitative affects on the human body following radiation exposure. Review of cell biology and interactions of radiation with matter. Tissue radio-sensitivity, cellular, intracellar, and systemic responses to radiation. Critical organ and dose calculations and risk-to-benefit factors. Radiation exposure to the fetus and late effects. Prerequisites: Health care experience within the last three years or permission of program director or department chair.
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MCCCD Official Course Competencies:
 
NMT202   19906-20032 Radiation Biology
1. Discuss specific concepts of cell biology to include cell structure and cell division. (I)
2. Describe the major interactions between radiation and matter to include linear energy transfer, ionization, relative biological effectiveness, and the target theory. (II)
3. Explain the radiosensitivity of specific different tissues in the human body. (III)
4. Explain specific cellular and intracellular responses to radiation and factors affecting it. (IV)
5. Explain the level and types of specific systemic responses to radiation. (V)
6. Describe and calculate specific critical organ exposure and dose. (VI)
7. Explain risks and the medical benefits to radiation exposure. (VII)
8. Explain radiation exposure to the fetus to include effect vs. dose, effect vs. stage of development, and protection recommendations. (VIII)
9. Describe specific late effects of radiation exposure on the human body. (IX)
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MCCCD Official Course Outline:
 
NMT202   19906-20032 Radiation Biology
    I. Cell Biology
        A. Cell structure
          1. Cell membrane
          2. Organelles
          3. Nucleus
          4. Chromosomes
        B. Cell division
          1. Mitosis
          2. Meiosis
      II. Interactions
          A. Linear energy transfer
          B. Ionization
          C. Relative Biological Effectiveness -- quality factors
          D. Target theory
        III. Tissue Radiosensitivity
            A. Law of Bergonie and Tribondeau
            B. Blood
              1. Red blood cells
              2. Lymphocytes
            C. Bone
            D. Fat
            E. Muscle
            F. Connective tissue
            G. Nerve tissue
          IV. Cellular and Intracellular Responses
              A. Interphase death vs. reproductive death
              B. Survival curves
              C. Effects on the cell cycle
              D. Physical factors
              E. Chemical factors
              F. Biological factors
            V. Systemic Responses
                A. Hemopoietic syndrome
                B. Gastrointestinal syndrome
                C. Central nervous system syndrome
                D. Total-body response
                  1. Dose levels
                  2. Manifestations
                  3. Cellular behavior
              VI. Critical Organ Exposure and Dose Calculations
                  A. Influencing factors of absorbed dose
                    1. Concentration
                    2. Time
                    3. Type of radiation
                    4. Energy emitted
                    5. Fraction absorbed
                  B. Critical Organ
                    1. Critical organ for given radiopharmaceutical
                    2. Target organ for given procedure
                  C. Calculations
                    1. Classical and MIRD methods
                    2. Formulas
                    3. S.I. conversions
                    4. Charts and tables
                VII. Risk and Benefits
                    A. Pathological damage
                      1. Cells and tissues
                      2. Organ and systems
                      3. Total body
                    B. Diagnostic exposures
                      1. Risks
                      2. Benefits
                      3. Alternatives
                    C. Therapeutic exposures
                      1. Risks
                      2. Benefits
                      3. Alternatives
                  VIII. Exposure to the Fetus
                      A. Effect vs. dose
                      B. Effect vs. stage of development
                      C. Protection recommendations
                    IX. Late Effects of Radiation Exposure
                        A. Effect on aging
                        B. Genetic mutation
                        C. Incidence of cancer
                        D. Life shortening
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