Maricopa Community Colleges  NMT265   19906-20032 
Official Course Description: MCCCD Approval: 04/22/03
NMT265 19906-20032 LEC 5 Credit(s) 5 Period(s)
Nuclear Medicine Clinical Studies III
Anatomy/physiology and specific pathological conditions, radiopharmaceuticals, equipment, techniques, indications, patient preparation, and image interpretation for the endocrine system, soft-tissues and nonorgan systems. General radionuclide therapy pathology, techniques, rationale and specific procedures. Principles, theory and practices of radio- and non-radioactive assay. Introduction to Positron Emission Tomography (P.E.T.), Single-photon Emission Computerized Tomography (S.P.E.C.T.) and other imaging modalities. Prerequisites: NMT230 or permission of program director or department chair.
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MCCCD Official Course Competencies:
 
NMT265   19906-20032 Nuclear Medicine Clinical Studies III
1. Describe the general anatomy and physiology of the endocrine system to include the adrenal, pituitary, and parathyroid glands. (I)
2. Describe pathological conditions of the endocrine system to include hypoadrenalism, hyperadrenalism hyperfunctioning, hypofunctioning pituitary gland, and other specific forms of pathology. (II)
3. Explain imaging of the adrenal gland to include rationale, indications, patient preparation, radiopharmaceutical, equipment, technique, image interpretation, and other specific imaging techniques. (III)
4. Explain imaging of the parathyroid and pituitary glands to include rationale, indications, patient preparation, radiopharmaceutical, equipment, technique, and image interpretation. (IV)
5. Describe the anatomy and physiology of specific soft-tissue structures including, but not limited to, connective and nerve tissues. (V)
6. Describe pathological conditions of soft-tissue structures to include cellular inflammatory, neoplastic, chemical, allergic, congenital, idiopathic conditions and other specific forms of pathology. (VI)
7. Describe imaging procedures of the soft-tissues to include rationale, indications, patient preparation, radiopharmaceutical, equipment, technique, special considerations, image interpretation and other specific imaging techniques. (VII)
8. Describe the following nonorgan imaging studies to include combined liver/lung, breast, dacroscintigraphy, radionuclide venography, antibody imaging, in-vitro, LeVeen shunt procedures, and other special organ systems. (VIII)
9. Describe the specific pathology treated through therapeutic nuclear medicine techniques to include hyperthyroidism, thyroid carcinoma, euthyroid heart disease, polycythemia vera, chronic leukemia, malignant lymphoma, metastatic bone disease, malignant pericardial effusion, malignant peritoneal effusion, malignant pleural effusion, ovarian carcinoma, and other forms of pathology. (IX)
10. Describe the indications, preparation, quality control, and biological behavior of the radiopharmaceuticals used in nuclear medicine therapeutic procedures. (X)
11. Explain nuclear medicine therapeutic procedures to include patient preparation, personnel and laboratory preparation, administration of the radiopharmaceutical, post-therapeutic procedures, special considerations, and radiation safety. (XI)
12. Describe the principles of radioassay to include terminology, test substances, review of solution chemistry, competitive radioassay, sequential saturation analysis, sandwich assay, immunoradiometric assay, radioenzymatic assay, radioreceptor assay, and radioallergosorbent test. (XII)
13. Explain specific principles related to immunology to include terminology, nonspecific immunity, and specific immunity. (XIII)
14. Describe specific clinical techniques involved with radioassay to include equipment, data reduction, record keeping, quality assurance, troubleshooting, proficiency testing, radiation safety, specimen storage, infection control, and instrumentation quality control. (XIV)
15. Explain specific assay procedures to include pituitary and hypothalamic hormones, thyroid, parathyroids, adrenal glands, kidney, pancreas, digestive, ovaries and testes, hepatitis, and tumor-associated testing. (XV)
16. Explain nonradioactive assays to include enzyme-linked immunosorbent assay, enzyme multiplied immunoassay technique, and fluorometric studies. (XVI)
17. Describe fundamental principles of Positron Emission Tomography (P.E.T.) and Single-Photon Emission Computerized Tomography (S.P.E.C.T.) imaging to include theory, equipment, radiopharmaceuticals, indications, and applications. (XVII)
18. Describe other imaging modalities to include radiography, ultrasound, computerized tomography, and magnetic resonance. (XVIII)
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MCCCD Official Course Outline:
 
NMT265   19906-20032 Nuclear Medicine Clinical Studies III
    I. Anatomy and Physiology of the Endocrine System
        A. Thyroid gland
          1. Anatomical features
          2. Hormones
          3. Regulation
          4. Iodine trapping
        B. Adrenals
          1. Anatomical features
          2. Hormones
          3. Renal effects
          4. Cardiovascular effects
        C. Parathyroid gland
          1. Anatomical features
          2. Hormone
          3. Calcium and phosphate regulation
        D. Pituitary gland
          1. Anatomical features
          2. Hormones
          3. Relationship to hypothalamus
      II. Pathology of the Endocrine System
          A. Hypoadrenalism
          B. Hyperadrenalism
          C. Hypofunctioning pituitary gland
          D. Hyperfunctioning pituitary gland
          E. Other forms of pathology
        III. Imaging of the Adrenal Glands
            A. Rationale
            B. Indications
            C. Patient preparation
            D. Radiopharmaceutical
            E. Equipment
            F. Technique
            G. Image interpretation
            H. Other imaging techniques
          IV. Imaging of the Parathyroid and Pituitary Glands
              A. Rationale
              B. Indications
              C. Patient preparation
              D. Radiopharmaceutical
              E. Equipment
              F. Technique
              G. Image interpretation
              H. Other imaging techniques
            V. Anatomy and Physiology of Soft-tissue Structures
                A. Skin
                B. Fat tissue
                C. Connective tissue
                D. Nerve tissue
              VI. Pathological Conditions of Soft-tissue Structures
                  A. Cellular inflammatory conditions
                  B. Neoplastic conditions
                  C. Chemical injuries
                  D. Allergic reactions
                  E. Congenital conditions
                  F. Idiopathic conditions
                  G. Other forms of pathology
                VII. Imaging Procedures of the Soft-tissues
                    A. Rationale
                    B. Indications
                    C. Patient preparation
                    D. Radiopharmaceutical
                    E. Equipment
                    F. Technique
                    G. Special considerations
                      1. Pediatrics
                      2. Geriatrics
                    H. Image interpretation
                    I. Other imaging techniques
                  VIII. Nonorgan Imaging Studies
                      A. Combined liver/lung
                      B. Breast
                      C. Gallium
                      D. Tagged leukocyte
                      E. Dacroscintigraphy
                      F. Radionuclide venography
                      G. Antibody imaging
                      H. In-vitro
                      I. LeVeen shunt
                      J. Special organ systems
                        1. Fibrinogen uptake test
                        2. P-32 eye tumor localization
                        3. XE-133 muscle blood flow
                    IX. Therapeutic Nuclear Medicine Pathology
                        A. Hyperthyroidism
                        B. Thyroid carcinoma
                        C. Euthyroid heart disease
                        D. Polycythemia vera
                        E. Chronic leukemia
                        F. Malignant lymphoma
                        G. Metastatic bone disease
                        H. Malignant pericardial effusion
                        I. Malignant peritoneal effusion
                        J. Malignant pleural effusion
                        K. Ovarian carcinoma
                        L. Other forms of pathology
                      X. Pharmaceuticals/Therapeutic Procedures
                          A. Indications
                          B. Preparation
                          C. Quality control
                          D. Biological behavior
                        XI. Nuclear Medicine Therapeutic Procedures
                            A. Patient preparation
                            B. Personnel and laboratory preparation
                            C. Administration of the radiopharmaceutical
                            D. Post-therapeutic procedures
                            E. Special considerations
                              1. Pediatrics
                              2. Geriatrics
                            F. Radiation safety
                          XII. Principles of Radioassay
                              A. Terminology
                              B. Test substances
                              C. Review of solution chemistry
                              D. Competitive radioassay
                              E. Sequential saturation analysis
                              F. Sandwich assay
                              G. Immunoradiometric assay
                              H. Radioenzymatic assay
                              I. Radioeceptor assay
                              J. Radioallergosorbent test
                            XIII. Principles of Immunology
                                A. Terminology
                                B. Nonspecific immunity
                                C. Specific immunity
                              XIV. Clinical Techniques of Radioassay
                                  A. Equipment
                                  B. Data reduction
                                  C. Record keeping
                                  D. Quality assurance
                                  E. Troubleshooting
                                  F. Proficiency testing
                                  G. Radiation safety
                                  H. Specimen storage
                                  I. Infection control
                                  J. Instrumentation quality control
                                XV. Assay Procedures
                                    A. Pituitary and hypothalamic hormones
                                    B. Thyroid
                                    C. Parathyroids
                                    D. Adrenal glands
                                    E. Kidney
                                    F. Pancreas
                                    G. Digestive
                                    H. Ovaries and testes
                                    I. Hepatitis
                                    J. Tumor-associated testing
                                  XVI. Nonradioactive Assays
                                      A. Enzyme-linked immunosorbent assay
                                      B. Enzyme multiplied immunoassay technique
                                      C. Fluorometric studies
                                    XVII. P.E.T. and S.P.E.C.T. Imaging Fundamentals
                                        A. Theory
                                        B. Equipment
                                        C. Radiopharmaceuticals
                                          1. Production
                                          2. Administration
                                        D. Indications
                                        E. Applications
                                      XVIII. Imaging Modalities
                                          A. Radiography
                                          B. Ultrasound
                                          C. Computerized tomography
                                          D. Magnetic resonance
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