I. Fundamental Concepts of Pathology
A. Definition of pathology
B. Divisions of pathology
1. Pathological anatomy (morbid anatomy)
4. Physiological pathology
5. Medico-legal pathology (forensic pathology)
C. Plan of study in pathology
D. Autopsy as a tool in the advancement of medical science
1. Confirmation of medical diagnosis
2. Advancement medical knowledge and research
3. Assistance in medico-legal cases
4. Amplify or reject the clinical diagnosis
II. Characteristics of Disease
2. Relationship of cellular change to disease
a. The doctrine of cellular pathology: Virchow
3. Descriptive terminology relating to disease
B. Etiology: the study of the cause of disease
1. Predisposing conditions
a. Trauma: mechanical injury
b. Physical agents: heat, cold, electricity, X-ray
3. Chemical agents: drugs and poisons
4. Plant and animal parasites: bacteria, molds, yeasts,
protozoa, viruses
5. Deficiency of essential substances
III. Cellular Reaction to Injury
A. Types of regressive cellular changes
(c). Dry (ischemic necrosis)
IV. Structural Abnormalities
A. Malformation or anomaly
V. Inflammation and Repair
VI. Disturbances in Circulation
1. Physiological and pathological hyperemia
2. Active and passive hyperemia
a. Injuries to blood vessels
b. Slow rate of blood flow
c. Alterations in blood composition
3. Changes in thrombi (fragmentation)
4. Consequences of thrombosis
2. Consequences of embolism
b. Infarction or gangrene
F. Infarction and infarct
b. Diseases of blood vessels
2. Terms related to hemorrhage
VII. Neoplasms and Cysts
1. Classification of neoplasms
a. Clinical: based on behavioral characteristics
b. Histological: based on the type of tissue from which the
tumor arises
(1). Type of growth: expansive vs. infiltrative
1. Derived from epithelium
2. Derived from connective tissue
3. Derived from muscle: myoma
4. Derived from nervous tissue: neuroma
1. Derived from epithelium
b. Squamous cell carcinoma
2. Derived from connective tissue
3. Derived from muscle: myosarcoma
4. Derived from nervous tissue: glioma
2. Post mortem conditions
e. Extravascular obstruction
VIII. Diseases of the Blood
1. Due to destruction or loss of red blood cells
2. Due to decreased production of red blood cells
C. Hematopoietic disorders
3. Polycythemia vera (erythrocytosis)
IX. Diseases of the Heart and Blood Vessels
b. Post mortem conditions
(1). Possible vascular obstruction
(2). Possible multiple abscesses
b. Valvular insufficiency (incompetence)
7. Rheumatic heart disease
8. Coronary heart disease
X. Diseases of the Digestive System
A. Mouth and associated parts
C. Esophagus: esophagitis
E. Small intestines: enteritis
1. Degeneration and infiltration
b. Post mortem conditions
H. Gall bladder and bile ducts
I. Pancreas: pancreatitis
J. Peritoneum: peritonitis
2. Post mortem conditions
d. Rapid coagulation of blood
3. Febrile lesions (vesicles)
XI. Diseases of the Respiratory Tract
A. The upper respiratory tract
1. Pneumonia: pneumonitis
(2). Pleural effusion: hydrothorax
c. Post mortem conditions
(1). Rapid coagulation of blood
d. Post mortem conditions
XII. Diseases of the Urinary System
A. Terms dealing with urinary disturbances
C. Diseases of the kidney
G. Urethritis and stricture of urethra
XIII. Diseases of the Nervous System
4. Intracranial hemorrhage
(1). Extradural hemorrhage
(3). Subarachnoid hemorrhage
XIV. Diseases of the Female Reproductive System
2. Tubal extopic pregnancy
XV. Diseases of the Male Reproductive System
XVI. Diseases of the Bones and Joints
XVII. Diseases of the Endocrine Glands
(2). Vascular obstruction
2. Hyperthyroidism: Grave's disease
2. Waterhouse-Friderichsen syndromem
XVIII. The Coroner and Medical Examiner
XIX. Medicolegal Investigation
A. Type of death with medicolegal potential
1. Injury and death by violence
a. Missile wounds: gunshot, other projectiles
b. Sharp force injury: stabbing, cutting
c. Blunt force injury: blows, falls
d. Land, water, aircraft accidents
2. Sudden and/or unexpected death
c. Not in the care of a physician
4. Health, welfare and safety
a. Malpractice/negligence
B. Determination of jurisdiction
1. Medical examiner's case
1. Absolute identification of the body
2. Description of the body and scene
3. Description of the clothing
4. Unrestricted autopsy with accessory investigations
a. Biochemical (toxicological)
e. Evidential information: recovery and preservation
XX. Injuries
1. Abrasion: superficial injury (scratch)
2. Ecchymosis: escape of blood into tissue of a living person
following a rupture of vessels
3. Laceration: splitting or tearing apart of tissues
4. Avulsion: loss of tissues from tearing away
B. Incised wounds: appearance site
1. Hesitation marks (multiple, shallow: usually suicide)
2. Defense (injury, homicide)
D. Stab or puncture wounds: appearance, site (obscure)
1. Through clothing (homicide)
2. Not through clothing (suicide)
E. Wounds and injury by gunshot
1. Heat exhaustion: exposure to excessive heat
b. General: death from chilling
b. External signs of hanging
c. Posture and clothing of the victim
d. Accidental (sexual deviation vs. suicide)
(a). Cases of sexual assault
(b). Infanticide (umbilical cord)
(c). Garrotting (criminal execution)
c. Traumatic or crush asphyxia
XXI. Sudden Infant Death Syndrome (S.I.D.S.)
XXII. Maltreatment of Children
XXIII. Poisoning
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